AFSOS-SFRO Guidelines on Radiation-Induced Lung Injury

Area of Science:

• Oncology
• Radiation Oncology
• Pulmonary Medicine

Background:

• Radiation-induced lung injury (RILI) is a significant complication following thoracic radiotherapy.
• Clinical manifestations of RILI vary widely, from asymptomatic changes to severe pneumonitis and fibrosis.
• The increasing use of thoracic irradiation and complex treatments like immunotherapy necessitate standardized RILI management.

Purpose of the Study:

• To provide expert recommendations for the clinical management of RILI.
• To guide clinicians in the diagnosis, grading, and supportive care of RILI.
• To improve the quality and consistency of care for patients undergoing thoracic radiotherapy.

Main Methods:

• Development of consensus guidelines by the French Society of Radiation Oncology (SFRO) and the French Association for Supportive Care in Oncology (AFSOS).
• Inclusion of key topics: clinical risk factors, differential diagnosis, toxicity-based therapeutic strategies, role of corticosteroids and supportive treatments, follow-up, and prevention.
• Multidisciplinary approach to RILI management.

Main Results:

• Established clear diagnostic criteria and grading systems for RILI.
• Outlined evidence-based therapeutic strategies tailored to RILI severity.
• Provided recommendations for supportive care, follow-up, and preventive measures.

Conclusions:

• Standardized guidelines are essential for optimal clinical management of RILI.
• These recommendations aim to enhance patient outcomes and reduce RILI-related morbidity.
• A multidisciplinary approach ensures consistent and high-quality care for patients at risk of RILI.