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The renin-angiotensin system (RAS) and arthritic diseases: therapeutic potential for RAS inhibitors

Yasser H Habib1, Mahmoud Khattab2, Mennatallah A Gowayed3

  • 1Zi Diligence Center-Quality Pharmaceutical Services, Cairo, Egypt. yasserhabib1994@outlook.com.

Inflammopharmacology
|August 12, 2025
PubMed

Insights

The renin-angiotensin system (RAS) plays a dual role in arthritis, with one axis promoting inflammation and another offering protection. Targeting RAS pathways shows promise for managing inflammatory arthritis and improving patient outcomes.

Area of Science:

  • Endocrinology
  • Immunology
  • Rheumatology

Background:

  • The renin-angiotensin system (RAS) is crucial for cardiovascular and renal homeostasis.
  • RAS is increasingly recognized for its role in inflammatory arthritis, including rheumatoid arthritis (RA) and osteoarthritis (OA).

Purpose of the Study:

  • To review the dual role of the RAS in arthritis pathogenesis and progression.
  • To explore the therapeutic potential of modulating RAS in arthritis treatment.
  • To discuss emerging strategies like AI-powered personalized medicine for RAS-targeted therapies.

Main Methods:

  • Literature review of studies investigating RAS components and function in arthritis.
  • Analysis of clinical data on RAS inhibitors (ARBs, ACEIs) in arthritis patients.
  • Exploration of research on the counter-regulatory RAS axis (ACE2/Ang-(1-7)/MasR).

Main Results:

  • The classical RAS axis (ACE/Ang II/AT1R) contributes to inflammation and joint damage in arthritis.
  • The counter-regulatory axis (ACE2/Ang-(1-7)/MasR) demonstrates anti-inflammatory and protective effects.
  • RAS inhibitors show efficacy in reducing inflammatory markers, oxidative stress, and immune dysregulation in arthritis.

Conclusions:

  • Modulating the RAS offers a promising therapeutic avenue for inflammatory arthritis.
  • The counter-regulatory RAS axis presents a novel target for protective strategies.
  • Integrating RAS modulation with AI-driven personalized medicine could revolutionize arthritis treatment.
Keywords:
ACEIsAI-powered personalized medicineARBsOsteoarthritisRenin–angiotensin systemRheumatoid arthritis

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