Related Experiment Video
Updated: Sep 11, 2025
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
Published on: May 14, 2021
Myofibroblastoma of the breast in a 5-year-old girl: A case report
Youn Joo Jung1,2, Ayoung Kang1,2,3, Miri Ryu1,2
1Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.
Insights
Pediatric breast masses can rarely be myofibroblastomas, a benign tumor. Complete surgical excision is effective for this rare condition in children, with no reported recurrence.
Area of Science:
- Oncology
- Pediatric Surgery
- Pathology
Background:
- Myofibroblastoma is a rare, benign breast stroma tumor.
- Predominantly affects older males and postmenopausal females; exceedingly rare in children.
Purpose of the Study:
- To report a rare case of pediatric breast myofibroblastoma.
- Highlight the diagnostic and management considerations for this rare pediatric tumor.
Main Methods:
- A 5-year-old girl presented with a palpable left breast mass.
- Ultrasound monitoring for one year, followed by surgical excision due to progressive enlargement.
- Histopathological and immunohistochemical analysis confirmed the diagnosis.
Main Results:
- A 3 cm well-defined, yellow-white solid mass was surgically excised.
- Postoperative recovery was uneventful.
- No recurrence has been observed to date.
Conclusions:
- Myofibroblastoma is a rare but important consideration in pediatric breast masses.
- Complete surgical excision is the recommended treatment.
- Regular follow-up is advised for pediatric patients diagnosed with myofibroblastoma.
Rationale:
Myofibroblastoma is a rare, benign spindle cell tumor originating from the breast stroma. Although it predominantly affects older men and occasionally postmenopausal women, its occurrence in children is exceedingly rare.
Patient Concerns:
A 5-year-old girl presented with a palpable mass on the lateral aspect of her left breast.
Diagnoses:
Serial ultrasound examinations were conducted every 6 months for 1 year because the lesion was initially suspected to be a lipoma or an enlarged lymph node.
Interventions:
Owing to progressive enlargement of the mass to 3 cm, surgical excision was performed. A well-defined yellow-white solid mass located in the subcutaneous layer was completely removed.
Outcomes:
The histopathological and immunohistochemical findings confirmed the diagnosis of a myofibroblastoma. The postoperative course was uneventful, and no recurrence has been reported to date.
Lessons:
Although extremely rare, myofibroblastoma should be considered in the differential diagnosis of enlarged breast masses in children. Complete surgical excision is the treatment of choice, and regular follow-up is recommended.
