Reevaluating the diagnosis of right coronary artery absence: A thoughtful analysis of a case report

Xiaowei Wang1, Honggen Cui, Zhanwen Xu

  • 1Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, China.

Medicine
|August 13, 2025
PubMed

Insights

Rethinking coronary angiography (CAG) and computed tomography angiography (CTA) for right coronary artery (RCA) agenesis is crucial. Multimodal imaging is essential to prevent misdiagnosing rare coronary anomalies.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Anatomical Variations

Background:

  • Diagnostic challenges in identifying rare coronary artery anomalies persist.
  • Previous case reports on right coronary artery (RCA) agenesis require critical reevaluation.
  • The accuracy of coronary angiography (CAG) and computed tomography angiography (CTA) in diagnosing RCA agenesis is questioned.

Purpose of the Study:

  • To reevaluate the diagnostic certainty of CAG and CTA in a case of suspected RCA agenesis.
  • To highlight the importance of multimodal imaging in diagnosing rare coronary anomalies.
  • To prevent misdiagnosis of congenital coronary artery variations.

Main Methods:

  • A 57-year-old male presented with myocardial infarction symptoms.
  • CAG revealed left circumflex artery (LCX) occlusion and suggested LCX supplied the RCA territory.
  • Coronary CTA indicated RCA absence, but with diagnostic uncertainties.

Main Results:

  • Reanalysis of CAG showed no LCX supply to the RCA territory.
  • CTA findings suggested a possible coronary vein misinterpreted as an anomalous RCA.
  • The case likely represents a left-dominant system with a small, anomalous RCA, not agenesis.

Conclusions:

  • This case underscores the limitations of CAG and CTA in diagnosing rare coronary anomalies.
  • Multimodal imaging is critical for accurate interpretation of coronary anatomy.
  • Misinterpretation can lead to incorrect diagnoses and potentially inappropriate management strategies.
Abstract

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
30
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
46
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
34
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
37
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
57