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Updated: Sep 11, 2025

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Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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Fast and high-resolution multimode fiber speckle imaging via optical coherence control
Optics Express
|August 13, 2025
Summary
This study introduces a novel optical coherence control method to significantly speed up speckle imaging in multimode fibers (MMFs). The technique uses hybrid speckle patterns for parallel sampling, enhancing imaging speed while maintaining high resolution and fidelity.
Area of Science:
- Optics
- Biomedical Imaging
- Fiber Optics
Background:
- Speckle imaging via multimode fibers (MMFs) offers minimally invasive, high-resolution imaging.
- Current serial sampling methods in MMF speckle imaging are limited by slow acquisition speeds.
Purpose of the Study:
- To develop a novel method for fast and high-resolution speckle imaging through MMFs.
- To overcome the speed limitations of traditional serial sampling techniques.
Main Methods:
- Utilized optical coherence control to generate both single-speckle and incoherent hybrid speckle patterns.
- Employed hybrid speckle patterns for parallel sampling to increase imaging speed.
- Applied the method to perturbation rejection MMF imaging systems.
Main Results:
- Achieved a Q-fold increase in sampling speed, where Q is the number of single speckle patterns per hybrid pattern.
- Reconstructed images demonstrated high fidelity with structural similarity indices >= 0.75.
- Maintained high image quality with peak signal-to-noise ratios >= 15.5 dB.
Conclusions:
- The proposed optical coherence control method significantly enhances MMF speckle imaging speed without compromising image quality.
- Hybrid speckle pattern illumination enables parallel sampling, a novel approach for accelerating MMF imaging.
- The technique is compatible with perturbation rejection systems, broadening its applicability.
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