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Surveillance of laparoscopic systemic para-aortic lymphadenectomy for patients with intermediate- and high-risk endometrial cancer in Japan

  • 0Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
The Journal of Obstetrics and Gynaecology Research +

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August 13, 2025

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August 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Laparoscopic para-aortic lymphadenectomy (PALN) is a feasible and safe procedure for intermediate- and high-risk endometrial cancer. This multicenter study demonstrated acceptable complication rates and oncologic outcomes, supporting its use in clinical practice.

Area Of Science

  • Gynecologic Oncology
  • Minimally Invasive Surgery
  • Surgical Oncology

Background

  • Endometrial cancer staging often requires para-aortic lymphadenectomy (PALN).
  • Laparoscopic PALN offers potential benefits over open procedures, but its feasibility in a multicenter setting needs evaluation.

Purpose Of The Study

  • To assess the feasibility and safety of laparoscopic systemic para-aortic lymphadenectomy (PALN) for endometrial cancer.
  • To analyze surgical outcomes, complications, and prognosis in a multicenter cohort.

Main Methods

  • Prospective data collection from 403 patients undergoing laparoscopic PALN for intermediate- and high-risk endometrial cancer in Japan (July 2017-March 2020).
  • Analysis included clinical background, surgical outcomes, perioperative complications, and patient prognosis.

Main Results

  • The study included 403 patients with various endometrial cancer subtypes.
  • Median blood loss was 110 mL, with a 1.7% transfusion rate and 5.0% intraoperative complication rate.
  • Postoperative complications occurred in 13.2% of patients; risk factors for complications included blood loss, pelvic lymph node count, and radical hysterectomy.

Conclusions

  • Laparoscopic PALN is a feasible and safe surgical option for managing intermediate- and high-risk endometrial cancer.
  • The procedure demonstrated acceptable complication rates and oncologic outcomes in a multicenter setting.

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