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Taxifolin: Approaches to Increase Water Solubility and Bioavailability
Mark B Plotnikov1,2, Anna M Anishchenko1,3
1Department of Pharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3 Lenin ave., Tomsk, 634028, Russia.
Current Pharmaceutical Biotechnology
|August 13, 2025
Summary
Taxifolin (TAX), a flavonoid with therapeutic potential, faces bioavailability challenges due to poor solubility. This review explores technologies, especially nanotechnologies, to enhance TAX solubility and improve drug development.
Area of Science:
- Pharmacology
- Drug Delivery
- Flavonoid Chemistry
Background:
- Taxifolin (TAX), a dihydroquercetin, is a flavonoid with significant pharmacological effects and commercial interest.
- Its therapeutic application is hindered by poor physicochemical properties and unfavorable pharmacokinetics, including absorption, distribution, metabolism, and excretion.
- Enhancing TAX solubility is crucial for improving its bioavailability and clinical utility.
Purpose of the Study:
- To review technological methods for improving the solubility and bioavailability of Taxifolin (TAX).
- To highlight the efficacy of various formulation strategies for TAX delivery.
Main Methods:
- Micronization
- Crystal engineering
- Self-microemulsifying systems
- Liposomes and modifications
- Microemulsifying systems
- Phospholipid nanoparticles
- Inclusion complexes (clathrate generation)
- Chemical modification
Main Results:
- Several technological approaches have demonstrated success in enhancing TAX solubility and bioavailability.
- Nanotechnology-based methods, including liposomes and nanoparticles, are particularly effective.
- These advanced formulations significantly improve the delivery and therapeutic potential of TAX.
Conclusions:
- Technological interventions, particularly nanotechnologies, offer promising solutions to overcome TAX solubility and bioavailability limitations.
- Developing novel TAX formulations with enhanced properties is key to creating innovative therapeutic agents.
- Improved TAX bioavailability paves the way for new drug development and expanded medical applications.
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