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Bioimpedance a Diagnostic Tool for Tobacco-induced Oral Lesions - A Mixed Model Cross-sectional Study
Vaibhav Gupta1, Poonam Goel1, Usha Agrawal1
1CRIB Lab, National Institute of Pathology - ICMR, Delhi, India.
Introduction:
Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer, and basal cell carcinoma. The current study aimed to validate and evaluate bioimpedance as a diagnostic tool for tobacco-induced oral lesions.
Methodology:
The study comprised 50 oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) tissue specimens for in vitro study and 320 subjects for in vivo study. Bioimpedance device prepared and calibrated. EIS measurements were done for the habit and control groups and were compared.
Results:
The impedance value in the control group was significantly higher compared to the OPMD and OSCC groups. Diagnosis based on bioimpedance spectroscopy measurements has a sensitivity of 95.9% and a specificity of 86.7%.
Conclusion:
Bioimpedance device can help in decision-making for differentiating OPMD and OSCC cases and their management, especially in primary healthcare settings.
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