A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium

Area of Science:

• Ophthalmology and Gerontology
• Biomarker Discovery
• Public Health

Background:

• Age-related vision impairment significantly impacts the quality of life in aging populations.
• China faces unique challenges due to its large aging demographic.
• Effective interventions for visual system aging are crucial.

Purpose of the Study:

• To develop a consensus statement on biomarkers for visual system aging.
• To establish a multi-dimensional evaluation framework for assessing visual health.
• To guide early detection and disease progression insights.

Main Methods:

• Integrating cutting-edge global research.
• Synthesizing evidence-based medicine with clinical expertise.
• Developing a consensus statement by the Aging Biomarker Consortium (ABC) of China.

Main Results:

• A multi-dimensional framework encompassing functional, morphological, and molecular biomarkers.
• Recommended validated biomarkers for early detection of vision changes.
• Biomarkers providing insights into age-related ocular disease progression.

Conclusions:

• The consensus provides a framework to advance visual health management in aging societies.
• Early detection and understanding disease progression are key to improving outcomes.
• This initiative aims to benefit elderly populations in China and globally.