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Related Experiment Videos

Haloperidol-induced dyskinesias in the monkey.

P Bédard, J Delean, J Lafleur

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |August 1, 1977
    PubMed
    Summary

    Long-term haloperidol administration in monkeys caused persistent movement disorders, including tremor and oro-facial dyskinesias, even after drug cessation. Neuropathological examination revealed no central nervous system alterations.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Primatology

    Background:

    • Haloperidol is a typical antipsychotic used to treat psychosis.
    • Movement disorders are known side effects of haloperidol treatment.
    • The long-term effects and persistence of these side effects require further investigation.

    Purpose of the Study:

    • To investigate the long-term effects of chronic haloperidol administration on motor function in non-human primates.
    • To determine if haloperidol-induced movement disorders persist after drug cessation.
    • To correlate behavioral changes with neuropathological findings.

    Main Methods:

    • Six normal monkeys received daily intramuscular injections of haloperidol (0.25 mg/kg) for six months.
    • Observed behavioral symptoms including akathisia, circling, akinesia, choreoathetoid and dystonic movements, oro-facial dyskinesias, and postural tremor.

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  • Assessed persistence of symptoms six months after haloperidol cessation, with and without harmaline challenge.
  • Conducted neuropathological examination of the central nervous system.

    • Main Results:

    • Chronic haloperidol administration induced various movement disorders in monkeys.
    • Postural tremor, exacerbated by harmaline, persisted in all animals six months after haloperidol cessation.
    • Oro-facial abnormal movements persisted in one monkey six months post-cessation.
    • Neuropathological studies revealed no alterations in the central nervous system.

    Conclusions:

    • Chronic haloperidol use can lead to persistent, long-lasting movement disorders in primates.
    • The absence of neuropathological changes suggests that these persistent motor deficits may involve functional rather than structural alterations in the CNS.
    • Further research is needed to elucidate the mechanisms underlying these persistent haloperidol-induced movement disorders.