Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.6K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.6K
Cell Size01:22

Cell Size

118.0K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
118.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heritable single-cell gene expression states shape functional variability in innate immune responses.

bioRxiv : the preprint server for biology·2026
Same author

Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.

Science advances·2026
Same author

The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast.

bioRxiv : the preprint server for biology·2026
Same author

Impact of variability in cell generation times on cell-to-cell variability of protein concentrations.

bioRxiv : the preprint server for biology·2026
Same author

Enhancer placement impacts transcriptional dynamics in Drosophila embryos.

Nature communications·2026
Same author

Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration.

Nature communications·2026
Same journal

Trajectory Landscapes for Therapeutic Strategy Design in Agent-Based Tumor Microenvironment Models.

IEEE control systems letters·2026
Same journal

Blood Pressure Prediction During Blood Transfusion: A Population-Informed Multi-Modal Sequential Inference Approach.

IEEE control systems letters·2026
Same journal

Control of Subpopulation Fractions in a Population of Bistable Cells.

IEEE control systems letters·2025
Same journal

One-Shot Averaging for Distributed TD(<i>λ</i>) Under Markov Sampling.

IEEE control systems letters·2025
Same journal

Modeling Control of Supercoiling Dynamics and Transcription Using DNA-Binding Proteins.

IEEE control systems letters·2024
Same journal

An Anticipatory Scheme for the Model Predictive Control of Circadian Phase for Expected Environmental Light Changes.

IEEE control systems letters·2024
See all related articles

Related Experiment Video

Updated: Sep 11, 2025

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

6.2K

A Moments-Based Analytical Approach for Cell Size Homeostasis.

César Nieto1, Cesar Augusto Vargas-Garcia2, Abhyudai Singh3

  • 1Department of Electrical and Computer Engineering, University of Delaware, Newark, DE 19716 USA.

IEEE Control Systems Letters
|August 13, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals that regulated cell division rates are crucial for maintaining stable cell size. Stochastic Hybrid Systems modeling shows that size-dependent division rates, unlike size-independent ones, prevent unbounded increases in cell size variance.

Keywords:
Systems biologyhybrid systemsstochastic systems

More Related Videos

In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses
07:26

In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses

Published on: December 5, 2019

8.0K
Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture
09:04

Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture

Published on: February 23, 2018

9.6K

Related Experiment Videos

Last Updated: Sep 11, 2025

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

6.2K
In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses
07:26

In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses

Published on: December 5, 2019

8.0K
Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture
09:04

Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture

Published on: February 23, 2018

9.6K

Area of Science:

  • Quantitative Biology
  • Cellular Dynamics
  • Mathematical Modeling

Background:

  • Cell size regulation is fundamental for cellular function and organism development.
  • Previous models often simplified the complex dynamics of cell growth and division.
  • Understanding cell size homeostasis is key to deciphering cellular robustness.

Purpose of the Study:

  • To explore and model the mechanisms governing single-cell size dynamics and homeostasis.
  • To investigate the impact of different division rate strategies on cell size variability.
  • To develop a framework for parameter estimation from experimental cell size data.

Main Methods:

  • Utilized Stochastic Hybrid Systems (SHS) to model continuous cell growth and discrete division events.
  • Analyzed scenarios with size-independent and size-dependent division rates.
  • Derived exact formulas for steady-state moments (mean, variance, skewness) of cell size.

Main Results:

  • A size-independent division rate leads to unbounded increases in cell size variance over time.
  • A division rate proportional to cell size (the 'adder' model) achieves cell size homeostasis.
  • Multi-stage division processes and uneven daughter cell partitioning were modeled, showing reduced variability with more stages.

Conclusions:

  • Cell size homeostasis is achieved through specific size-dependent division control mechanisms.
  • The SHS framework provides quantitative insights into cell size variability reduction.
  • The study offers a method for parameter estimation, aiding experimental validation and understanding of cell size regulation.