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Updated: Sep 11, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
Published on: June 29, 2022
Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential
Shuai Zhao1,2, Aaron M Johnston3, Chi Him Kendrick Yiu3
1Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Abstract:
Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention that may be able to prevent and/or improve the current treatment paradigms for age-related AF. This review contributes to a holistic understanding of the intricate relationship between aging and AF.
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