Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuronal inhibitory mechanisms in overweight/obesity and food/eating addiction: The role of frontal brain coherence, dysregulated eating, and depressive symptoms.

Journal of behavioral addictions·2026

Same author

Application of voxel-wise SAR efficiency to evaluate suitability of novel materials in MRI with parallel transmit.

Physics in medicine and biology·2026

Same author

Timing Is Everything: How Subtle Timing Changes in MRI Echo Planar Imaging Can Significantly Alter Mechanical Vibrations and Sound Level.

Magnetic resonance in medicine·2026

Same author

Comparison of <math><msub><mi>B</mi> <mn>1</mn></msub></math> <sup>+</sup> and SAR efficiency for a high-impedance metamaterial shield with different remote RF arrays at 7 T MRI: A simulation study.

Magma (New York, N.Y.)·2025

Same author

Timing is everything: How subtle timing changes in MRI echo planar imaging can significantly alter mechanical vibrations and sound level.

ArXiv·2025

Same author

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Investigating the effective temporal resolution in a task-based functional MRI experiment at 7 T MRI using a dynamic

Guy Baz^1,2, Rita Schmidt^1,2

¹Weizmann Institute of Science, Department of Brain Sciences, Rehovot, Israel.

Imaging Neuroscience (Cambridge, Mass.)

|August 13, 2025

Summary

Researchers quantified the effective temporal resolution (ETR) in fMRI scans using a dynamic phantom. Optimizing parameters like multi-echo EPI and considering brain region properties can achieve high temporal resolution for studying brain responses.

Keywords:

functional MRI multi-echo temporal resolution ultra-high field MRI

More Related Videos

Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents

Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents

Published on: April 15, 2016

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Published on: June 30, 2018

Related Experiment Videos

Last Updated: Jul 2, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents

Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents

Published on: April 15, 2016

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

Published on: June 30, 2018

Area of Science:

Neuroimaging
Magnetic Resonance Imaging (MRI)
Functional Magnetic Resonance Imaging (fMRI)

Background:

fMRI studies increasingly aim to measure time delays in brain responses.
High sampling rates are crucial for accurately discerning these time delays.
Ultra-high field MRI and accelerated imaging techniques enable higher sampling rates.

Purpose of the Study:

To define and quantify the effective temporal resolution (ETR) of fMRI scans.
To investigate the impact of various scanning and paradigm parameters on ETR.
To assess ETR in different brain regions with varying tissue properties.

Main Methods:

Utilized a dynamic phantom to generate a "ground truth" signal with controlled onset delays.
Quantified ETR by systematically varying parameters: echo time (TE), repetition time (TR), voxel size, contrast-to-noise ratio (CNR).
Examined multi-echo echo-planar imaging (EPI) and fMRI paradigm parameters (block length/density).

Main Results:

Multi-echo EPI data acquisition improved ETR, reducing it significantly.
ETR was estimated at 151 ms (cortex) and 248 ms (basal ganglia) with a 600 ms TR when using multi-echo data.
Low CNR substantially increased ETR, sometimes exceeding the TR; physiological fluctuations also impacted ETR.

Conclusions:

Demonstrated the feasibility of achieving very short ETR in fMRI for studying time responses.
Emphasized the critical need to evaluate the attainable ETR for specific experimental conditions and brain regions.
Highlighted the influence of CNR and tissue properties on achievable temporal resolution in fMRI.