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Related Experiment Video

Updated: Sep 11, 2025

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Electric-field-based dosing for TMS.

Ole Numssen1,2, Philipp Kuhnke1,3, Konstantin Weise2,4

  • 1Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Imaging Neuroscience (Cambridge, Mass.)
|August 13, 2025
PubMed
Summary
This summary is machine-generated.

Electric field (e-field) based transcranial magnetic stimulation (TMS) dosing can reduce variability in non-invasive brain stimulation (NIBS). This approach enhances stimulation strength consistency across individuals and brain regions, improving research and personalized medicine applications.

Keywords:
NIBSTMScognitioncortical stimulation thresholddosingtESvariability

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Neuromodulation

Background:

  • Transcranial magnetic stimulation (TMS) is a key non-invasive brain stimulation (NIBS) method.
  • High variability in TMS efficacy and reliability hinders its clinical and research applications.

Purpose of the Study:

  • To explore electric field (e-field) based TMS dosing as a strategy to reduce variability.
  • To discuss current challenges and future directions for e-field dosing in NIBS.

Main Methods:

  • Investigated e-field modeling for TMS dosing.
  • Compared e-field dosing to traditional TMS dosing approaches.

Main Results:

  • E-field dosing demonstrates potential for more consistent stimulation strength across cortical areas and individuals.
  • Identified methodological uncertainties in e-field simulation and target definition as key challenges.

Conclusions:

  • E-field based TMS dosing offers a promising avenue to improve the precision and reproducibility of NIBS.
  • Addressing current challenges is crucial for realizing the full potential of e-field dosing in neuroscience and personalized medicine.