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Related Experiment Video

Updated: Sep 11, 2025

Iris Fixation via External Pentagram Suturing
05:22

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Internal Limiting Membrane Flap Enhances Macular Hole Closure Rates in Highly Myopic Eyes: A Case-Control Study.

Stanley S J Poh1,2, Andrew S H Tsai1,2, Hung-Da Chou3,4

  • 1Singapore National Eye Centre, Singapore.

Clinical Ophthalmology (Auckland, N.Z.)
|August 13, 2025
PubMed
Summary
This summary is machine-generated.

Macular hole (MH) surgery outcomes are comparable between high myopia (HM) and non-HM eyes. Surgical success in MH repair depends on smaller hole size and internal limiting membrane (ILM) flap technique, not axial length.

Keywords:
high myopiainternal limiting membrane flapinternal limiting membrane peelmacular hole

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Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Myopia Research

Background:

  • High myopia (HM) presents unique challenges for macular hole (MH) surgery.
  • Understanding surgical outcomes in HM is crucial for patient management.

Purpose of the Study:

  • To compare anatomical and functional outcomes of MH surgery in high myopia (HM) versus non-HM eyes.
  • To identify factors influencing surgical success in MH repair.

Main Methods:

  • Retrospective case-control study of MH repair (2018-2022).
  • HM defined by axial length (AL) ≥26 mm.
  • Comparison of best corrected visual acuity (BCVA) and anatomical outcomes between HM and non-HM groups, analyzing surgical techniques (ILM peel vs. flap) and MH characteristics.

Main Results:

  • Comparable BCVA and outer retinal layer restoration between HM and non-HM groups.
  • Initial hole closure rates were similar (85.3% in HM vs. 88.2% in non-HM).
  • ILM flap technique showed higher success rates than ILM peel (p=0.022). Smaller MH size correlated with better closure (OR 0.99).

Conclusions:

  • Anatomical success in MH repair is comparable between HM and non-HM eyes.
  • Surgical success is associated with smaller MH size and ILM flap technique.
  • Axial length, macular curvature, and foveoschisis did not significantly influence hole closure.