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Related Experiment Video

Updated: Sep 11, 2025

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

28.6K

Altered brain state dynamics between preterm and term-born infants.

Srikanth R Damera1, Sudeepta Basu1, Kushal Kapse1

  • 1Developing Brain Institute, Children's National, Washington, DC, United States.

Imaging Neuroscience (Cambridge, Mass.)
|August 13, 2025
PubMed
Summary

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Preterm birth impacts infant brain network dynamics, shifting infants away from a key "Transmodal State" towards sensory processing or dissociated networks. This highlights altered brain development beyond static network changes.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Brain Imaging

Background:

  • Preterm birth significantly affects infant brain development.
  • Previous research focused on static brain networks, overlooking dynamic brain states.
  • Brain state dynamics are crucial for understanding cognitive processes.

Purpose of the Study:

  • To identify distinct brain states in infants.
  • To investigate the influence of prematurity on the dynamics of these brain states.
  • To compare brain network dynamics between term-born and preterm-born infants.

Main Methods:

  • Applied Leading Eigenvector Analysis (LEiDA) to resting-state fMRI data.
  • Analyzed data from term (n=86) and preterm (n=102) infants post term equivalent age.
Keywords:
LeiDAbrain statesdefault mode networkdynamic functional connectivityneonatal fMRIpreterm birth

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Related Experiment Videos

Last Updated: Sep 11, 2025

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

28.6K
Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
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Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

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Infant Auditory Processing and Event-related Brain Oscillations

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  • Identified four discrete brain states common to both groups.

    • Main Results:

    • Confirmed previously identified infant brain states in an independent dataset.
    • Term-born infants spent more time in a "Transmodal State" (similar to adult Default-Mode Network).
    • Preterm infants showed altered transitions from the Transmodal state, favoring sensory processing or cortical-subcortical dissociation.

    Conclusions:

    • Preterm birth alters not only static brain networks but also dynamic brain network states.
    • These findings suggest prematurity impacts functional brain development at a dynamic level.
    • Understanding these dynamic changes is crucial for infant neurodevelopmental research.