Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic reconfiguration of subunits from the hippocampal-amygdala complex indicate patterns of psychosis vulnerability in 22q11.2 deletion syndrome.

Scientific reports·2026
Same author

Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.

IEEE open journal of engineering in medicine and biology·2026
Same author

The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.

bioRxiv : the preprint server for biology·2026
Same author

Fundamental limitations of kilohertz-frequency carriers in afferent fibre recruitment with transcutaneous spinal cord stimulation.

Nature biomedical engineering·2026
Same author

Functional properties of the handwriting brain network: Effects of motor sequence and spatial adaptation constraints.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

A diffusion MRI-derived perivascular metric related to glymphatic-associated processes in bipolar disorder vulnerability: Multimodal correlates across emotion dysregulation patients and offspring.

Psychiatry research·2026

Related Experiment Video

Updated: Sep 11, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.8K

Towards personalized mapping through lumbosacral spinal cord task fMRI.

Sergio Daniel Hernandez-Charpak1,2,3, Nawal Kinany2,4, Ilaria Ricchi2,4

  • 1Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.

Imaging Neuroscience (Cambridge, Mass.)
|August 13, 2025
PubMed
Summary

Functional magnetic resonance imaging (fMRI) can map the human lumbosacral spinal cord

Keywords:
fMRIlumbosacralmusclespinal cordtask

More Related Videos

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

6.8K
Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
11:29

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

Published on: April 20, 2019

9.8K

Related Experiment Videos

Last Updated: Sep 11, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.8K
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

6.8K
Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
11:29

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

Published on: April 20, 2019

9.8K

Area of Science:

  • Neuroscience
  • Functional Magnetic Resonance Imaging (fMRI)
  • Spinal Cord Research

Background:

  • The lumbosacral spinal cord's neural circuits are vital for locomotion.
  • Individual variations in spinal innervation pose challenges for therapeutic interventions.
  • Non-invasive functional mapping of muscle innervation (projectome) is essential.

Purpose of the Study:

  • To develop and validate a functional magnetic resonance imaging (fMRI) pipeline for mapping the human lumbosacral spinal cord's functional organization.
  • To assess spinal cord activity using blood oxygenation level dependent (BOLD) signals during various motor and sensory conditions.
  • To investigate the feasibility of creating personalized spinal cord projectomes.

Main Methods:

  • Developed an fMRI pipeline to record BOLD signals in the lumbosacral spinal cord.
  • Assessed spinal activity in 12 healthy participants during active movements, passive stretches, and tendon vibrations of leg muscles.
  • Utilized a decision tree framework combining anatomical MRI and fMRI data for personalized projectome reconstruction.

Main Results:

  • BOLD activity patterns were predominantly ipsilateral to the stimulus (movement, stretch, vibration).
  • fMRI-derived innervation maps showed variable alignment with existing invasive study data.
  • Significant inter-individual variability in BOLD activity patterns was observed.

Conclusions:

  • fMRI offers a proof-of-concept for mapping the lumbosacral spinal cord's functional organization non-invasively.
  • Personalized mapping of spinal projections is crucial for targeted therapies and neurosurgery.
  • Challenges remain in interpreting and standardizing fMRI-derived spinal cord activity patterns.