Dynamic network features of functional and structural brain networks support visual working memory in aging adults
Josh Neudorf1,2, Kelly Shen1,2, Anthony R McIntosh1,2
1Institute for Neuroscience and Neurotechnology, Simon Fraser University, Burnaby, Canada.
Imaging Neuroscience (Cambridge, Mass.)
|August 13, 2025
Summary
As we age, brain network dynamics and structural connectivity adapt to support visual working memory (VWM). Specific network transitions become more efficient, aiding cognitive function in older adults.
Area of Science:
- Neuroscience
- Cognitive Science
- Brain Network Dynamics
Background:
- Visual working memory (VWM) capacity and precision decline with age after peaking in early adulthood.
- Understanding age-related changes in brain network connectivity is crucial for cognitive health.
Purpose of the Study:
- To investigate how the relationship between structural and functional brain connectivity changes across the lifespan to support VWM.
- To identify age-specific network dynamics and structural underpinnings of VWM performance.
Main Methods:
- Analysis of functional brain network dynamics associated with VWM across different age groups.
- Network control theory simulations to model the impact of structural connectivity on functional transitions.
- Examination of structural connectivity differences in relation to VWM performance across the lifespan.
Main Results:
- Default Mode Network and Fronto-Parietal Network states were associated with better VWM performance.
- Older adults showed enhanced transitions from Visual/Somatomotor to Attention Network states, linked to better VWM.
- Structural connectivity supporting these transitions varied by age, with specific networks being more critical in younger versus older adults.
Conclusions:
- Structural connectivity facilitates flexible functional brain dynamics that support VWM across the lifespan.
- Age-related adaptations in network transitions and structural connectivity contribute to maintained VWM.
- Findings may inform interventions to preserve VWM function throughout aging.
Keywords:
diffusion-weighted magnetic resonance imagingdynamic functional connectivityhealthy agingnetwork control theoryresting-state functional magnetic resonance imagingvisual working memoryMore Related Videos
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