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Formulation and Characterization of Cerium Ion Cross-Linked Alginate/PVA Films for Wound Dressing Applications

  • 0Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Türkiye.
Biopolymers +

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August 13, 2025

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August 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

New cerium(III) cross-linked alginate films with poly(vinyl) alcohol show promise for wound dressings. These advanced biomaterials exhibit rapid fluid absorption and moisture transmission, essential for effective wound healing.

Area Of Science

  • Biomaterials Science
  • Polymer Chemistry
  • Wound Healing Technology

Background

  • Alginate films are widely explored for biomedical applications.
  • Developing advanced wound dressings requires materials with specific fluid management properties.
  • Cerium (Ce) incorporation can impart beneficial characteristics to biomaterials.

Purpose Of The Study

  • To formulate and characterize novel cerium(III) cross-linked alginate (Ce/Alg) films.
  • To investigate the effect of poly(vinyl) alcohol (PVA) incorporation on film properties.
  • To evaluate the potential of these films as wound coverage dressings.

Main Methods

  • Alginate films were prepared using the casting method and cross-linked with cerium(III) ions via acid treatment.
  • Poly(vinyl) alcohol was incorporated into the alginate matrix.
  • Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) were used for characterization.
  • Swelling behavior in phosphate-buffered saline (PBS) and water, and water vapor permeability were assessed.

Main Results

  • The incorporation of PVA did not alter the chemical structure of the Ce/Alg films, as confirmed by FTIR and DSC.
  • SEM analysis revealed a porous structure in the cerium-alginate films.
  • The films demonstrated rapid swelling within 10 minutes in PBS and water.
  • The cerium-alginate films exhibited significant water vapor permeability.

Conclusions

  • Cerium(III) cross-linked alginate films, enhanced with PVA, possess favorable biomaterial properties.
  • The rapid fluid absorption and moisture transmission capabilities suggest suitability for wound environments.
  • These developed films hold potential for future applications as efficient wound coverage dressings.

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