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Related Experiment Video

Updated: Sep 11, 2025

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Yin Yang 1: Role in Leishmaniasis.

Devki Nandan¹, Dilraj Kaur Longowal¹, Neil Reiner¹

¹Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

|August 13, 2025

Summary

This summary is machine-generated.

Leishmania parasites manipulate host macrophages using the Yin-Yang 1 (YY1) protein to ensure survival. This review details YY1

Keywords:

Yin Yang 1 host–pathogen interactions leishmaniasis macrophages parasitic infections transcription factors

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Last Updated: Sep 11, 2025

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

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Published on: April 21, 2012

Area of Science:

Parasitology
Immunology
Molecular Biology

Background:

Leishmaniasis is a neglected tropical disease caused by Leishmania parasites.
Understanding macrophage-Leishmania interactions is key to leishmaniasis research.
Leishmania employs strategies to survive within host macrophages.

Purpose of the Study:

To review how Leishmania utilizes the Yin-Yang 1 (YY1) protein.
To highlight YY1 as a virulence factor in macrophage survival.
To present an atlas of YY1-dependent proteins in human macrophages.

Main Methods:

Review of existing literature on Leishmania-macrophage interactions.
Analysis of the role of Yin-Yang 1 (YY1) in parasite survival.
Compilation of data on YY1-dependent proteins in macrophages.

Main Results:

Leishmania parasites exploit the host macrophage Yin-Yang 1 (YY1) protein.
YY1 acts as a critical proxy virulence factor for parasite survival.
An atlas of YY1-dependent proteins in human macrophages is provided.

Conclusions:

YY1 is a crucial factor exploited by Leishmania for intracellular survival.
The YY1-dependent protein atlas can aid future research into leishmaniasis.
Further investigation into YY1's role can reveal new therapeutic targets.