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Yin Yang 1: Role in Leishmaniasis
Devki Nandan1, Dilraj Kaur Longowal1, Neil Reiner1
1Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Cells
|August 13, 2025
Summary
Leishmania parasites manipulate host macrophages using the Yin-Yang 1 (YY1) protein to ensure survival. This review details YY1
Area of Science:
- Parasitology
- Immunology
- Molecular Biology
Background:
- Leishmaniasis is a neglected tropical disease caused by Leishmania parasites.
- Understanding macrophage-Leishmania interactions is key to leishmaniasis research.
- Leishmania employs strategies to survive within host macrophages.
Purpose of the Study:
- To review how Leishmania utilizes the Yin-Yang 1 (YY1) protein.
- To highlight YY1 as a virulence factor in macrophage survival.
- To present an atlas of YY1-dependent proteins in human macrophages.
Main Methods:
- Review of existing literature on Leishmania-macrophage interactions.
- Analysis of the role of Yin-Yang 1 (YY1) in parasite survival.
- Compilation of data on YY1-dependent proteins in macrophages.
Main Results:
- Leishmania parasites exploit the host macrophage Yin-Yang 1 (YY1) protein.
- YY1 acts as a critical proxy virulence factor for parasite survival.
- An atlas of YY1-dependent proteins in human macrophages is provided.
Conclusions:
- YY1 is a crucial factor exploited by Leishmania for intracellular survival.
- The YY1-dependent protein atlas can aid future research into leishmaniasis.
- Further investigation into YY1's role can reveal new therapeutic targets.
