Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy

Area of Science:

• Nanomedicine
• Biochemistry
• Medical Applications of Ozone

Background:

• Ozone (O3) is a highly oxidative gas with therapeutic applications dating back to the early 20th century.
• Low-dose ozone therapy leverages moderate oxidative stress to stimulate cellular antioxidant defenses, offering anti-inflammatory and regenerative effects.
• Ozone's potent antibacterial, antimycotic, and antiviral properties are valuable in various medical fields, but its chemical instability limits applications.

Purpose of the Study:

• To review nanocarriers designed for medical ozone (O3) delivery.
• To explore the therapeutic applications of these novel ozone formulations.
• To highlight the current state and future prospects of nanotechnology in ozone therapy.

Main Methods:

• Review of scientific literature on nanocarrier-based ozone delivery systems.
• Analysis of studies investigating the in vitro and in vivo efficacy of nanocarrier-delivered ozone.
• Identification of various nanocarrier types used for ozone administration.

Main Results:

• Several nanocarriers, including liposomes, nanobubbles, nanoconstructed hydrogels, polymeric nanoparticles, and niosomes, have been developed for ozone delivery.
• These nanocarrier systems have demonstrated antiseptic, anticancer, and pro-regenerative effects.
• Research in nanotechnological delivery of ozone is active and productive, though relatively new.

Conclusions:

• Nanotechnology offers promising solutions for overcoming the stability and administration limitations of medical ozone (O3).
• Nanocarrier-based ozone formulations show significant potential for antiseptic, anticancer, and regenerative therapies.
• Further research and development in this nascent field hold multiple prospects for advancing ozone therapy.