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Updated: Sep 11, 2025

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion
Klaus Ebnet1, Michel Aurrand-Lions2
1Institute-associated Research Group "Cell adhesion and cell polarity", Institute of Medical Biochemistry, ZMBE, University of Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany. ebnetk@uni-muenster.de.
None:
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive system, or cells of the hematopoietic system. Through trans-homophilic as well as trans-heterophilic interactions with the JAM family member JAM-B and with members of the integrin family JAM-C regulates diverse processes including epithelial barrier formation, leukocyte- endothelial interactions and transendothelial migration, neuronal cell migration along glial fibers, myelin sheath integrity, and germ cell migration. In this article, we review the biological activities of JAM-C, including its basic organization, its extracellular and intracellular interaction partners, and its diverse physiological functions.
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