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Updated: Sep 11, 2025
08:15
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
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Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion
Klaus Ebnet1, Michel Aurrand-Lions2
1Institute-associated Research Group "Cell adhesion and cell polarity", Institute of Medical Biochemistry, ZMBE, University of Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany. ebnetk@uni-muenster.de.
Cellular and Molecular Life Sciences : CMLS
|August 13, 2025
Summary
Junctional Adhesion Molecule-C (JAM-C) is a cell adhesion molecule regulating tissue integrity and cell migration. This review details JAM-C
Area of Science:
- Cell Biology
- Molecular Biology
- Immunology
Background:
- Junctional Adhesion Molecule-C (JAM-C) is a key cell adhesion molecule.
- It is expressed across various tissues, including epithelial, endothelial, and hematopoietic cells.
Purpose of the Study:
- To review the biological activities of JAM-C.
- To detail its organization, interaction partners, and physiological functions.
Main Methods:
- Literature review of JAM-C functions.
- Analysis of JAM-C interactions with JAM-B and integrins.
Main Results:
- JAM-C regulates epithelial barrier formation and leukocyte transendothelial migration.
- It plays roles in neuronal cell migration and myelin sheath integrity.
- JAM-C is involved in germ cell migration.
Conclusions:
- JAM-C is a versatile molecule with critical roles in diverse physiological processes.
- Understanding JAM-C interactions is vital for comprehending tissue development and immune responses.
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