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Updated: Sep 11, 2025

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Plummer-Vinson Syndrome: A Retrospective Multicenter Study.

Ahmed Elsayed Alzamzamy1,2, Mohammed Tag-Adeen3, Abdullah Zuhair Alyouzbaki4

  • 1Department of Gastroenterology and Hepatology, Military Medical Academy, Cairo, Egypt.

Digestive Diseases and Sciences
|August 13, 2025
PubMed
Summary

Plummer-Vinson syndrome (PVS) primarily affects middle-aged women and is linked to iron deficiency anemia (IDA). Endoscopic dilation is an effective treatment for PVS, often requiring only one session.

Keywords:
DysphagiaEndoscopic dilationEsophageal cancerEsophageal webIron deficiency anemiaPlummer-Vinson syndrome

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Area of Science:

  • Gastroenterology
  • Otolaryngology
  • Oncology

Background:

  • Plummer-Vinson syndrome (PVS) is a rare disorder characterized by dysphagia, iron deficiency anemia (IDA), and upper esophageal webs.
  • PVS is associated with an increased risk of esophageal squamous cell carcinoma (SCC).
  • Limited data exist on the comprehensive characteristics and management of PVS.

Purpose of the Study:

  • To analyze the demographic and clinical features of Plummer-Vinson syndrome.
  • To evaluate imaging findings and treatment outcomes for PVS across multiple centers.
  • To assess the risk of malignant transformation in PVS patients.

Main Methods:

  • A retrospective, multicenter study was conducted across seven tertiary GI endoscopy centers.
  • Medical records of 56 patients diagnosed with PVS between 2021 and 2024 were reviewed.
  • Data analyzed included clinical presentation, laboratory results, imaging, and treatment modalities.

Main Results:

  • The study included 56 patients (80.5% female, mean age 41 years) with PVS, all presenting with dysphagia and IDA.
  • Endoscopic dilation, primarily using Savary-Gilliard bougie dilators, was the main treatment, with 76.8% of patients responding to a single session.
  • A small percentage (7.1%) developed esophageal SCC/dysplasia during follow-up, with no significant post-dilation complications.

Conclusions:

  • Plummer-Vinson syndrome predominantly affects middle-aged women and is strongly associated with IDA.
  • Endoscopic dilation is an effective and safe treatment for PVS, often requiring a single intervention.
  • Close monitoring for malignant transformation is crucial in PVS patients due to the risk of esophageal SCC.