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Updated: Sep 11, 2025

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Chiral Porous Sheet Assembly for Multiple Chirality Induction in Macrocycle Formation
Yongsheng Li1, Tianyi Zheng1, Zhanting Li2
1Department of Chemistry, State Key Lab of Molecular Engineering of Polymers, and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China.
Abstract:
The stereochemistry of chiral macrocycles bearing multiple chirality has a crucial influence on their physical and biological properties. Nevertheless, the multiple chirality induction in macrocyclizations remains largely unexplored in the synthetic community. Here we report that confined macrocyclizations in single-layer chiral porous sheets can generate macrocyclic products bearing multiple chirality with excellent stereoselectivity. To induce multiple chirality in a confined macrocyclization, we used chiral porous sheet structures formed through the self-assembly of a planar aromatic amphiphile including a tilt rod. The chiral interior of the porous sheet imprints its stereochemistry on the conformation of a linear substrate, enabling the ring closing reaction to simultaneously induce multiple chirality, including a stereocenter and strain-induced chirality.
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