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Progeria Presenting with Pyogenic Granuloma in Conjunctiva: A Case Report
Sanket Parajuli1, Sadhana Sharma2, Tina Shrestha3
1Department of Ophthalmology, Reiyukai Eiko Masunaga Eye Hospital, Banepa, Kavrepalanchowk, Nepal.
JNMA; Journal of the Nepal Medical Association
|August 13, 2025
Summary
Hutchinson-Gilford progeria syndrome, a rare genetic condition, can present with unusual ocular complications. This case highlights a pyogenic granuloma in a teenage patient, emphasizing the need for vigilance in managing progeria patients.
Area of Science:
- Ophthalmology
- Genetics
- Dermatology
Background:
- Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and growth failure.
- Ocular manifestations are common in HGPS, but specific conditions like pyogenic granuloma are exceptionally rare.
Observation:
- A 17-year-old female with HGPS presented with a persistent red bump in her right eye.
- The ocular mass did not respond to initial medical treatments over a 3-month period.
Findings:
- Excisional biopsy confirmed the mass to be a pyogenic granuloma.
- This represents an extremely rare occurrence of pyogenic granuloma in a patient with HGPS.
Implications:
- This case underscores the importance of considering atypical ocular presentations in HGPS patients.
- Early recognition and management of such rare complications are crucial for healthcare professionals treating individuals with HGPS.
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