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Lipid nanoparticles for mRNA delivery in brain via systemic administration

Dinglingge Cao1, Xucheng Hou1, Chang Wang1

  • 1Icahn Genomics Institute, Precision Immunology Institute, Department of Immunology and Immunotherapy, Department of Oncological Sciences, Tisch Cancer Institute, Friedman Brain Institute, Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Science Advances
|August 13, 2025
PubMed
Summary

Researchers developed OS4T lipid nanoparticles (LNPs) for brain mRNA delivery. These LNPs significantly enhance mRNA translation in the brain, showing promise for treating glioblastoma and other central nervous system disorders.

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