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Association between mean corpuscular volume and mortality in chronic kidney disease ICU patients: A retrospective

Sheng Chen1, Yiwen Li1, Lin Guo1

  • 1Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Plos One
|August 13, 2025
PubMed

Insights

Higher mean corpuscular volume (MCV) in chronic kidney disease (CKD) intensive care unit (ICU) patients is linked to increased mortality. This finding suggests MCV may help identify high-risk CKD patients needing critical care.

Area of Science:

  • Nephrology
  • Hematology
  • Critical Care Medicine

Background:

  • Chronic kidney disease (CKD) impacts over 10% globally, increasing cardiovascular risks.
  • Mean corpuscular volume (MCV) is a hematological parameter linked to clinical outcomes.
  • The association between MCV and mortality in intensive care unit (ICU) CKD patients requires further investigation.

Purpose of the Study:

  • To investigate the relationship between MCV and mortality in CKD patients admitted to the ICU.
  • To determine if MCV can serve as a biomarker for risk stratification in this population.

Main Methods:

  • Retrospective multicenter cohort study using eICU-CRD and MIMIC-IV databases.
  • Kaplan-Meier survival curves and multivariable Cox proportional hazards models were used.
  • Restricted cubic splines assessed nonlinear relationships between MCV and mortality.

Main Results:

  • Higher MCV levels significantly correlated with increased 30-day and 90-day in-hospital mortality.
  • Kaplan-Meier analysis showed higher mortality risk with elevated MCV.
  • Cox models identified MCV as a significant mortality risk factor in CKD ICU patients.

Conclusions:

  • Elevated MCV is significantly associated with higher short-term mortality in CKD ICU patients.
  • MCV may function as a potential biomarker for risk stratification in critically ill CKD patients.
  • Further research is needed to validate these findings and elucidate underlying mechanisms.
Abstract

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