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CROI 2025: Metabolic and Other Complications of HIV Infection

Sudipa Sarkar1, Todd T Brown1

  • 1Johns Hopkins University, Baltimore, MD, USA.

Topics in Antiviral Medicine
|August 13, 2025
PubMed

Insights

New research from the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) highlights aging comorbidities in people with HIV (PWH). Studies focused on cardiovascular health, aging markers, and treatment impacts, offering crucial clinical insights.

Area of Science:

  • Infectious Diseases
  • Gerontology
  • Cardiology
  • Virology

Background:

  • Aging-related comorbid conditions significantly impact health, quality of life, and survival in people with HIV (PWH).
  • The 2025 Conference on Retroviruses and Opportunistic Infections (CROI) presented key findings on comorbidities in PWH.

Purpose of the Study:

  • To review and highlight clinically impactful abstracts from CROI 2025 concerning aging comorbidities in PWH.
  • To synthesize recent research on cardiovascular diseases, biologic aging markers, and treatment effects in PWH.

Main Methods:

  • Review of abstracts presented at CROI 2025.
  • Analysis of studies focusing on cardiovascular diseases (atherosclerosis, heart failure), epigenetic aging markers, and treatment interventions.
  • Inclusion of data from REPRIEVE trial ancillary analyses and global studies.

Main Results:

  • Cardiovascular diseases remain a major focus, with ongoing research from REPRIEVE and global cohorts.
  • Epigenetic markers of aging and the impact of treatments like glucagon-like peptide-1 receptor agonists were explored.
  • Cytomegalovirus suppression demonstrated benefits in reducing immune activation, inflammation, and improving physical function.
  • Switching to integrase strand transfer inhibitors was linked to increased diabetes and hypertension risk, independent of weight gain.

Conclusions:

  • CROI 2025 underscored the complex interplay between aging, comorbidities, and HIV management.
  • Emerging research highlights potential therapeutic targets and risks associated with specific HIV treatments.
  • Further investigation into cardiovascular health and aging biomarkers is crucial for improving long-term outcomes in PWH.

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