[Metabolically healthy obesity and cardiovascular risk: Analysis of risk scores in a large population cohort]
Related Experiment Video
Updated: Sep 11, 2025
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
M García Samuelsson1, P J Tárraga López2, A A López González3
1Grupo ADEMA-Salud, Instituto Universitario en Ciencias de la Salud (IUNICS), Palma de Mallorca, España; Facultad de Odontología, Escuela Universitaria ADEMA-UIB, Palma de Mallorca, España.
Introduction:
Metabolically healthy obesity (MHO) describes obese individuals without evident metabolic disturbances. However, its relationship with cardiovascular risk remains controversial.
Objective:
To assess cardiovascular risk using different risk scores among MHO individuals compared to metabolically unhealthy obese (MUO) and normal-weight subjects in a large cohort of Spanish workers.
Methods:
Cross-sectional study including 68,884 obese workers (45,498 men and 23,386 women). MHO and MUO were classified according to NCEP-ATPIII criteria. Cardiovascular risk was estimated using SCORE2, REGICOR, ERICE, DORICA, vascular age, and avoidable years of life lost.
Results:
MHO individuals exhibited a better risk profile than MUO subjects but significantly worse than normal-weight individuals. Across all evaluated scores, MUO individuals showed the highest risk values, particularly among men. Lower educational attainment, low social class, physical inactivity, and smoking were independently associated with increased cardiovascular risk.
Conclusions:
Although considered intermediate risk, MHO is not a clinically benign phenotype. Targeted preventive strategies are necessary to reduce the progression toward metabolically unhealthy states in this subgroup.
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