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JNK in inflammation and lipid metabolism regulation in atherosclerosis

Dan Tang1, Yi Yao2, Xing Xiang1

  • 1Department of Clinical Laboratory Medicine, Institution of microbiology and infectious diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Hunan Provincial Key Laboratory of Multi-omics And Artificial Intelligence of Cardiovascular Diseases, University of South China, Hengyang, Hunan, China; Clinical Research Center for Myocardial Injury in Hunan Province, Hengyang, Hunan, China; Institute of Cardiovascular Disease, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

International Immunopharmacology
|August 13, 2025
PubMed

Insights

Atherosclerosis involves complex regulation, with c-Jun N-terminal kinase (JNK) central to its development. Targeting JNK may offer new treatments for this systemic arterial disease.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Atherosclerosis is a systemic arterial disease marked by lipid buildup, inflammation, and endothelial dysfunction.
  • Complex, multifactorial regulation drives atherosclerosis pathogenesis.
  • c-Jun N-terminal kinase (JNK), a stress-activated kinase, is implicated in disease development.

Purpose of the Study:

  • To review the role of JNK in atherosclerosis.
  • To highlight JNK as a potential therapeutic target for atherosclerosis.

Main Methods:

  • This is a review article, synthesizing existing research on JNK's role in atherosclerosis.
  • Literature review focusing on molecular mechanisms and interorgan effects.

Main Results:

  • JNK regulates key pathogenic processes including oxidative stress, lipid metabolism, and inflammation.
  • Vascular injury activates JNK, amplifying inflammation and disease progression.
  • JNK influences vascular health via metabolic and inflammatory pathways in organs like the liver and kidneys.

Conclusions:

  • JNK plays a central role in the pathogenesis of atherosclerosis.
  • Targeting JNK pathways presents a promising therapeutic strategy for atherosclerosis.
  • Understanding JNK's interorgan effects is crucial for developing effective treatments.
Keywords:
AtherosclerosisInflammationJNKLipid metabolism

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