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hsa_circ_0004276 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells and exacerbates

BaiQuan Fu1, YuXin Sui1, Yu Liu1

  • 1Department of Orthopaedics, Chifeng Municipal Hospital, Chifeng City, Inner Mongolia Autonomous Region, China.

Clinics (Sao Paulo, Brazil)
|August 13, 2025
PubMed

Insights

Circular RNA hsa_circ_0004276 is highly expressed in postmenopausal osteoporosis (PMO) and interacts with ELAVL1 to regulate bone cell differentiation. This study highlights hsa_circ_0004276 as a potential diagnostic marker and therapeutic target for PMO.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Postmenopausal Osteoporosis (PMO) is a significant health concern.
  • Identifying reliable diagnostic markers and understanding molecular mechanisms are crucial for PMO management.

Purpose of the Study:

  • To investigate hsa_circ_0004276 as a diagnostic marker for PMO.
  • To explore the interaction between hsa_circ_0004276 and ELAVL1 in PMO pathogenesis.

Main Methods:

  • Differential expression analysis of circRNAs in PMO patients.
  • Validation of hsa_circ_0004276 structure and expression.
  • Assessment of hsa_circ_0004276 and ELAVL1 in serum samples.
  • In vitro studies on Bone Marrow Mesenchymal Stem Cells (BMSCs) osteogenic differentiation.

Main Results:

  • hsa_circ_0004276 was upregulated in PMO patients and correlated with lower bone mineral density.
  • hsa_circ_0004276 demonstrated high diagnostic accuracy for PMO.
  • hsa_circ_0004276 interacted with ELAVL1, affecting BMSC osteogenic differentiation.
  • ELAVL1 expression was reduced in PMO patients and positively correlated with hsa_circ_0004276.

Conclusions:

  • hsa_circ_0004276 regulates BMSC osteogenic differentiation via ELAVL1 interaction in PMO.
  • This study offers insights into PMO molecular mechanisms.
  • hsa_circ_0004276 presents a potential therapeutic target for PMO.
Abstract

Keywords:
ELAVL1Osteogenic differentiationPostmenopausal osteoporosisRNA-binding proteinhsa_circ_0004276

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