Feasibility of lock solutions for epicutaneo-caval catheters in neonates: the 'LOOSEN' pilot study

Epicutaneo-caval catheters are vital in neonatal care, but are prone to occlusion and infection. This pilot study evaluated whether a 1-h saline lock, combined with proper flushing and anti-reflux connectors, affects catheter patency in neonates. Catheter patency was assessed using infusion pressure (pre- and post-lock) as a surrogate measure. The findings support the feasibility and safety of short lock periods, thereby laying the groundwork for future use of antimicrobial lock solutions in neonatal care.