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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
The use of a reinforced tissue matrix (OviTex) in paediatric reconstructive surgery
Nick Engall1, Melanie Clarke2, Ross J Craigie1
1Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.
Insights
Ovine reinforced tissue matrix (ORTM) shows excellent safety and efficacy in pediatric reconstructive surgery for abdominal and thoracic wall defects. This innovative material significantly reduces hernia recurrence and complications compared to traditional methods.
Area of Science:
- Pediatric Surgery
- Biomaterials in Surgery
- Tissue Engineering
Background:
- Abdominal and thoracic reconstruction in children presents unique challenges due to growth and potential reoperations.
- Reinforced tissue matrices are crucial for pediatric reconstructive surgery, accommodating growth and future interventions.
Purpose of the Study:
- To evaluate the safety and efficacy of an ovine reinforced tissue matrix (ORTM) in pediatric abdominal and thoracic reconstructive surgery.
- To compare outcomes of ORTM use with historical data using alternative closure techniques.
Main Methods:
- A cohort analysis of 35 children undergoing reconstruction with ORTM (OviTEX®) between 2019-2024.
- Comparison with a historical cohort of 11 children who underwent abdominal wall reconstruction prior to ORTM use (2010-2019).
Main Results:
- No abdominal or thoracic wall hernia recurrences were observed in the ORTM group (n=35).
- The ORTM group experienced a low rate of surgical site occurrences (3%), with no infections related to the matrix.
- ORTM demonstrated significantly lower recurrence rates (0% vs 55%) compared to historical controls (p=0.002).
Conclusions:
- ORTM is a safe and effective option for pediatric reconstructive surgery, offering superior outcomes.
- The use of ORTM in pediatric patients is associated with excellent results and a low incidence of surgical site complications.
Aim:
Abdominal and thoracic reconstructive surgery has always been an aspect of paediatric surgery for conditions such as congenital abdominal wall defects and incisional herniae. Reinforced tissue matrices are ideal for the paediatric population as consideration needs to be given to future growth and potential reoperation. We present our experience with an ovine reinforced tissue matrix (ORTM), OviTex®, (TELA Bio, Malvern, PA, USA).
Methods:
All patients who underwent abdominal or thoracic reconstruction at our institutions using ORTM 2019-2024 were reviewed. A cohort analysis was done with patients undergoing abdominal wall reconstruction prior to the use of ORTM, 2010-2019.
Results:
The ORTM was used in 35 children, (21 male). Median age at insertion 4.3 years (2.1-6.9), weight 15.5 kg (9.4-28.3). The most common diagnoses were exomphalos major (n = 15), emergency laparotomy (n = 9), diaphragmatic hernia (n = 5). In the ORTM group there were no abdominal or thoracic wall hernia recurrences. There was one surgical site infection (SSI) unrelated to the ORTM. There was a surgical site occurrence (SSO) in 3 % (n = 1 skin dehiscence). Median follow up 8.5 months (3.7-14.3). Prior to the use of ORTM, alternative closure techniques were used in 11 children with exomphalos major (7 male). Compared to the ORTM group they had 55 % (n = 6) vs 0 % (n = 0) recurrences (p = 0.002), 9 % (n = 1) vs 0 % (n = 0) SSI (p = 0.42) and 36 % (n = 4) vs 0 % (n = 0) SSO (p = 0.02).
Conclusion:
Our series demonstrates that ORTM can be used safely in paediatric reconstructive surgery with excellent outcomes superior to other synthetic and biologic materials with a low rate of SSI/SSO.
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