Advancing biomaterial innovation for tissue engineering through microbial synthetic biology: A review

Microbial synthetic biology is a burgeoning discipline of resplendent innovation. Its primary objective is to enable microorganisms to synthesize specific substances or acquire diverse biological functions by modifying microbial genomes or regulating metabolic processes. With the ceaseless advancement of synthetic biology technology and the continuous deepening of research, microbial synthetic biology has achieved remarkable breakthroughs in the realm of biomaterial science, offering a new direction for designing advanced biomaterials for tissue engineering. In this review, we first outline commonly used microbial hosts and synthetic biology approaches related to biomaterials production. Then we focus on the classification of biomaterials produced by engineered microbes, explaining the production strategies for these different categories of biomaterials and the specific advantages of producing them using engineered microbes. We discuss the advancements and profound impacts of these innovative microbial-synthesized materials in the field of tissue engineering. Despite the challenges that lie ahead, the prospects for the application of these biomaterials in the field of tissue engineering remain exceedingly vast. In the future, microbial synthesized materials are expected to bring more innovations and breakthroughs to the field of tissue engineering.