Crossing a chasm: Patient partnership and preclinical pain research
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Patient partners enhance preclinical research by providing unique insights into pain, improving study relevance and outcomes. Addressing barriers to collaboration is crucial for accelerating scientific discovery and improving patient lives.
Area Of Science
- Preclinical research
- Patient engagement
- Pain research
Background
- Patient involvement in clinical research is increasingly valued.
- Patient partners/lived experience consultants are underutilized in preclinical pain research.
- This commentary is co-authored with a lived experience consultant.
Purpose Of The Study
- Highlight mutual benefits of integrating patient partners into discovery-based research.
- Propose actionable strategies for effective researcher-patient collaborations.
- Emphasize alignment of research with patient needs and priorities.
Main Methods
- Commentary co-authored by a lived experience consultant.
- Discussion of benefits, barriers, and strategies for patient-researcher collaboration.
- Focus on preclinical pain research and broader discovery science.
Main Results
- Patient partners offer unique insights into symptom burden, treatment outcomes, and model relevance.
- Integration enhances innovation, trust, transparency, advocacy, and knowledge translation.
- Barriers include limited access to patient networks, power imbalances, lack of training, and funding issues.
Conclusions
- Collaborative, bi-directional partnerships improve research alignment with patient needs.
- Addressing challenges requires structural support, education, and mandates.
- Effective collaboration accelerates scientific impact and improves health outcomes.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Detailed History: Understanding the patient's symptoms is critical. It includes inquiring about abdominal pain, weight loss, and digestive issues, which are common in chronic pancreatitis.
Physical Examination: This might reveal abdominal tenderness, jaundice, and signs of malnutrition,...
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...