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Updated: Sep 11, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
Published on: June 24, 2020
Clinical and Pathophysiological Characteristics of Patients in Whom Asthma Developed during Treatment with Immune
Ken Maeno1, Tomoko Tajiri1, Satoshi Fukuda1
1Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan.
Abstract:
Asthma develops as an immune-related adverse event; however, its clinical and pathophysiological characteristics remain unclear. We retrospectively reviewed five cases of asthma that developed during immune checkpoint inhibitor (ICI) treatment in patients with cancer. In all cases, a significant increase in blood eosinophil count was observed immediately before the onset of asthma symptoms, and serum allergen-specific immunoglobulin E antibodies were positive. ICI treatment could be continued safely, while temporarily suspended in two patients, under asthma treatment. The incidence of asthma was 0.97% (5/514). Early diagnosis and standard treatment enable good asthma control while continuing ICI therapy.
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