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[How to manage hypomagnesemia?]

Geoffrey Cheminet1, Aude Ritter2, Pascal Houillier3

  • 1Service de médecine interne, Centre national de référence des syndromes drépanocytaires majeurs de l'adulte, AP-HP, hôpital européen Georges-Pompidou, 75015 Paris, France; Inserm U1163, laboratoire « Mécanismes cellulaires et moléculaires des désordres hématologiques et implications thérapeutiques », Institut Imagine, université Paris Cité, 75015 Paris, France.

La Revue De Medecine Interne
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PubMed
Summary
This summary is machine-generated.

Hypomagnesemia, or low magnesium levels, requires more frequent screening due to its essential role in enzymatic processes. This review details its causes, diagnosis, and management strategies for better patient outcomes.

Keywords:
CauseHypomagnesemiaHypomagnésémieMagnesiumMagnésiumTraitementTreatment

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Physiology

Context:

  • Magnesium is a critical cofactor for numerous enzymatic reactions, particularly those involving adenosine triphosphate (ATP) and guanosine triphosphate (GTP).
  • Hypomagnesemia is a common electrolyte disturbance with diverse etiologies that necessitate thorough diagnostic evaluation.
  • Current clinical practice may not adequately screen for hypomagnesemia, potentially leading to delayed diagnosis and treatment.

Purpose:

  • To provide a practical overview of hypomagnesemia management.
  • To consolidate current knowledge on the pathophysiology, clinical presentation, and etiology of low magnesium.
  • To outline an effective diagnostic and therapeutic approach for hypomagnesemia.

Summary:

  • This review covers the fundamental physiological roles of magnesium, emphasizing its involvement in ATP/GTP-Mg dependent enzymes.
  • It details the clinical and biological signs indicative of hypomagnesemia and explores its multifactorial causes.
  • The article presents a structured diagnostic algorithm and discusses various treatment options for correcting magnesium deficiency.

Impact:

  • Increased awareness and screening for hypomagnesemia can lead to earlier detection and intervention.
  • A comprehensive understanding of hypomagnesemia management can improve patient care and prevent associated complications.
  • This practical guide serves as a valuable resource for clinicians managing patients with electrolyte imbalances.