Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

661
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
661
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

21.5K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
21.5K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.2K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.2K
Structural Isomerism02:34

Structural Isomerism

19.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.7K
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

2.9K
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
2.9K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

529
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
529

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design Rules for Selective Peptide Amphiphile-Gold Nanoparticle Interactions from Atomistic Simulations.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Exploring the Modularity of Triphenylphosphine-Containing Polymers as Diverse Transition Metal Catalysts.

ACS macro letters·2026
Same author

Insights into conformational ensembles of compositionally identical disordered peptidomimetics.

Polymer chemistry·2025
Same author

Structure-Function Insights into Thermoresponsive Copolymers as Lanthanide Precipitants.

Journal of the American Chemical Society·2024
Same author

Revisiting kinetic Monte Carlo algorithms for time-dependent processes: From open-loop control to feedback control.

The Journal of chemical physics·2024
Same author

Dynamic Implications of Noncovalent Interactions in Amphiphilic Single-Chain Polymer Nanoparticles.

ACS macro letters·2024
Same journal

Radical Cascades on Seawater Microdroplets Drive Atmospheric Mercury Oxidation.

Journal of the American Chemical Society·2026
Same journal

Superior Selective and Fast NH<sub>3</sub> Adsorption of Soft Porous MOF/Ionic Liquid Composites with Ordering Phase Transitions.

Journal of the American Chemical Society·2026
Same journal

Systematic Catalyst Variation for Improved Stereoselective Epoxide Polymerization: Subtle Modifications Resulting in Superior Efficiency.

Journal of the American Chemical Society·2026
Same journal

Deciphering the Halide Chemistry of Cl<sup>-</sup> and Br<sup>-</sup> in Enhancing Kinetics of Mg Plating/Stripping.

Journal of the American Chemical Society·2026
Same journal

Electrosynthesis of C<sub>6</sub> Chemicals by Propylene Oxidative Coupling on Au Surface.

Journal of the American Chemical Society·2026
Same journal

Statistical AI Enables Precise Screening of Multielement Catalysts.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Sep 11, 2025

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.3K

Structure-Function Relationships in Sequence-Controlled Copolymers for Rare Earth Element Chelation.

Matthew P Bogen1, William M Swofford1, Supraja S Chittari1

  • 1Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of the American Chemical Society
|August 13, 2025
PubMed
Summary
This summary is machine-generated.

Synthetic polymer sequence controls rare earth element (REE) binding. Researchers designed amphiphilic polymer chelators, varying composition and sequence, to tune metal affinity and selectivity for improved separations and catalysis.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.4K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

18.8K

Related Experiment Videos

Last Updated: Sep 11, 2025

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.3K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.4K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

18.8K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Biological macromolecules offer precise function control via sequence, a challenge for synthetic polymers due to dispersity.
  • Synthetic polymers lack predictable sequence-structure-function relationships, hindering applications in areas like metal separation.

Purpose of the Study:

  • To investigate how polymer composition and sequence patterning influence binding affinity and selectivity for rare earth elements (REEs).
  • To establish design principles connecting polymer sequence, structure, and binding performance for synthetic chelators.

Main Methods:

  • Synthesized a library of amphiphilic copolymers with varying hydrophobic monomer composition and patterning (statistical, gradient, block) using RAFT polymerization.
  • Quantified REE binding using a high-throughput colorimetric assay and employed kinetic stochastic simulations to analyze sequence heterogeneity.
  • Utilized dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) to study polymer conformation and assembly, complemented by analysis of metal coordination and desolvation effects.

Main Results:

  • Demonstrated that polymer sequence and architecture significantly impact REE binding affinity and selectivity.
  • Linked local monomer colocalization to emergent REE binding properties through sequence heterogeneity analysis.
  • Observed that polymer architecture and hydrophobic content modulate metal-induced conformational changes and multichain assembly.
  • Found nonmonotonic differences in REE selectivity across polymers with identical composition but different sequence architectures.

Conclusions:

  • Established clear design principles linking polymer sequence and structure to binding performance for synthetic chelators.
  • Showcased the potential for tailored polymer design to enhance affinity and selectivity for REEs.
  • Highlighted the utility of these findings for advancing applications in separations, sensing, and catalysis.