Association between triglyceride-glucose index combinations and infertility: findings from a nationally...

Area of Science:

• Reproductive Health
• Metabolic Syndrome
• Public Health

Background:

• Infertility is a growing public health concern with limited research on its link to triglyceride-glucose (TyG) index indicators.
• This study investigates the association between infertility and three composite TyG-related indices: TyG-BMI, TyG-WC, and TyG-WHtR.

Purpose of the Study:

• To examine the relationship between infertility and TyG-BMI, TyG-WC, and TyG-WHtR.
• To identify potential metabolic risk factors for infertility.

Main Methods:

• Utilized data from 2856 adult participants in the 2013-2020 National Health and Nutrition Examination Survey.
• Calculated TyG-related indices using fasting triglyceride and glucose levels with anthropometric measurements.
• Employed weighted multivariate logistic regression, subgroup analyses, and threshold effect modeling to assess associations.

Main Results:

• Significant positive associations were found between infertility and TyG-BMI, TyG-WC, and TyG-WHtR.
• Subgroup analyses revealed consistent associations in specific populations, including Mexican American, married, and non-Hispanic White participants.
• No nonlinear relationships were observed between these indices and infertility.

Conclusions:

• TyG-BMI, TyG-WC, and TyG-WHtR are identified as risk factors for infertility.
• These findings underscore the importance of TyG-related metabolic indicators in reproductive health.
• Further research is needed to elucidate the pathophysiological mechanisms linking these metabolic indicators to infertility.