Regulation of transcriptome plasticity by mTOR signaling pathway.

Area of Science:

• Molecular Biology
• Cellular Biology
• Genetics

Background:

• The mechanistic target of rapamycin (mTOR) pathway is crucial for cellular metabolism and growth.
• Emerging evidence highlights mTOR's significant role in regulating the transcriptome.
• mTOR influences RNA processing, impacting proteome diversity and function.

Purpose of the Study:

• To review the multifaceted roles of mTOR in modulating transcriptome plasticity.
• To explore mTOR's influence on RNA processing beyond traditional functions.
• To discuss the implications of mTOR-mediated transcriptome plasticity in adaptation and pathogenesis.

Main Methods:

• Comprehensive review of recent scientific literature.
• Analysis of studies investigating mTOR's impact on alternative splicing and polyadenylation.
• Examination of mTOR's role in cellular responses to environmental and metabolic cues.

Main Results:

• mTOR significantly modulates transcriptome plasticity through RNA processing.
• mTOR-mediated RNA processing allows dynamic cellular adaptation to cues.
• This regulation impacts protein function and cellular behavior contextually.

Conclusions:

• mTOR's regulation of RNA processing is vital for physiological responses and disease development.
• Understanding mTOR's role in transcript diversity is key for cancer research, potentially driving tumor heterogeneity and treatment resistance.
• Comprehensive knowledge of these mechanisms is essential for developing targeted therapies.