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Consensus on acromegaly therapeutic outcomes: an update.
Shlomo Melmed1, Luigi di Filippo2, Maria Fleseriu3
1Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nature Reviews. Endocrinology
|August 13, 2025
Summary
Updated guidelines for acromegaly management incorporate new treatments. Experts reviewed evidence on somatostatin receptor ligands, pegvisomant, and cabergoline to optimize therapeutic outcomes and clinical algorithms.
Area of Science:
- Endocrinology
- Internal Medicine
- Pharmacology
Background:
- Acromegaly management guidelines were last updated in 2018.
- Recent advancements include new pharmacological agents and treatment strategies.
- The 15th Acromegaly Consensus Conference convened in September 2023.
Purpose of the Study:
- To update recommendations on therapeutic outcomes for acromegaly.
- To assess the impact of new and existing pharmacologic agents on acromegaly control.
- To provide an optimized, evidence-based algorithm for acromegaly management.
Main Methods:
- Fifty-two acromegaly management experts reviewed current literature.
- Assessment of drug approvals, clinical practice standards, and management strategies.
- Evaluation of somatostatin receptor ligands, pegvisomant, and cabergoline efficacy.
Main Results:
- New pharmacological agents and treatment approaches have emerged since 2018.
- Current evidence supports the use of specific agents for biochemical and clinical control.
- Factors influencing pharmacological choices and agent utilization were assessed.
Conclusions:
- Consensus recommendations for optimizing acromegaly management were established.
- An evidence-based algorithm for clinical practice was proposed.
- Updated strategies aim to improve therapeutic outcomes in acromegaly patients.
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