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Structural Posterior Fossa Malformations: MR Imaging and Neurodevelopmental Outcome
Jorden Halevy1,2, Hadar Doitch Amdurski1,3, Michal Gafner3,4
1Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel.
Diagnostics (Basel, Switzerland)
|August 14, 2025
Summary
Fetal MRI diagnoses of posterior fossa malformations are increasing. This study found that fetuses with these malformations may have normal long-term neurodevelopmental outcomes if no other anomalies are present.
Area of Science:
- Neuroscience
- Developmental Biology
- Radiology
Background:
- Fetal MRI use is rising, leading to more posterior fossa malformation diagnoses.
- Long-term neurodevelopmental outcomes for these fetuses are not well-understood.
Purpose of the Study:
- To investigate the long-term neurodevelopmental outcomes of fetuses diagnosed with structural posterior fossa malformations via fetal MRI.
Main Methods:
- A historical cohort study compared fetuses with and without posterior fossa malformations using fetal brain MRI (2011-2019).
- Neurodevelopmental outcomes were assessed using the Vineland Adaptive Behavior Scales II (VABS-II).
- Evaluated malformation types, additional anomalies (structural, genetic), and outcomes.
Main Results:
- 126 fetuses included: 56 with posterior fossa malformations, 70 controls.
- No significant overall neurodevelopmental differences between groups (93.4 vs. 99.8).
- Motor skills were lower in the malformation group (87.7 vs. 99.3) but within normal limits.
Conclusions:
- Fetuses with structural posterior fossa malformations can have normal neurodevelopment if comprehensive prenatal screening (sonography, genetics, MRI) reveals no additional anomalies.
- Further research with larger cohorts and longer follow-up is recommended to confirm findings and aid clinical decisions.
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