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Advances in Vulvar Cancer: A Radiation Oncology Perspective
Diandra N Ayala-Peacock1, Manjeet Chadha2
1Duke University Medical Center Department of Radiation Oncology, Durham, NC 27710, USA.
Cancers
|August 14, 2025
Summary
Management of vulvar cancer is evolving with less invasive surgeries and advanced treatments like radiotherapy and systemic agents. Further research is needed to clarify high-risk features and personalize treatment strategies based on risk stratification.
Area of Science:
- Gynecologic Oncology
- Cancer Treatment Innovation
Background:
- Vulvar cancer management is undergoing significant changes.
- Traditional approaches are being refined with new therapeutic strategies.
Purpose of the Study:
- To review advancements in vulvar cancer treatment.
- To highlight innovations in surgical, radiotherapeutic, and systemic approaches.
- To discuss ongoing debates in pathology and adjuvant therapy.
Main Methods:
- Comprehensive literature review.
- Analysis of treatment innovations and progress.
- Examination of evolving understanding of precursor lesions and subtypes.
Main Results:
- Progress in de-escalating surgical resection.
- Advancements in radiotherapy dose escalation.
- Incorporation of modern systemic agents for improved outcomes.
- Developing a nuanced understanding of vulvar cancer subtypes beyond HPV status.
Conclusions:
- Continued debate exists regarding high-risk pathology and adjuvant treatments.
- A deeper understanding of precursor lesions and subtypes is emerging.
- Future trials will focus on risk-stratified management recommendations.
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