Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simplified dosing method for initiating vancomycin therapy.

K D Lake, C D Peterson

    Pharmacotherapy
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Peripherally mediated opioid combination therapy in mouse and pig.

    The journal of pain·2024
    Same author

    Immunosuppressive drugs and novel strategies to prevent acute and chronic allograft rejection.

    Seminars in respiratory and critical care medicine·2005
    Same author

    Time to first graft loss as a risk factor for second renal allograft loss.

    Transplantation proceedings·2001
    Same author

    A retrospective assessment of safety, efficacy, and pharmacoeconomics of generic azathioprine in heart-transplant recipients.

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2001
    Same author

    Clinical pharmacy: looking 20 years back... looking 20 years forward.

    Pharmacotherapy·2000
    Same author

    Elevated free fractions of valproic acid in a heart transplant patient with hypoalbuminemia.

    The Annals of pharmacotherapy·2000
    Same journal

    The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers.

    Pharmacotherapy·2026
    Same journal

    Menopausal Hormone Therapy: A Narrative Review of Contemporary Evidence.

    Pharmacotherapy·2026
    Same journal

    Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

    Pharmacotherapy·2026
    Same journal

    Buprenorphine Initiation During Extracorporeal Membrane Oxygenation Decreases Sedative and Opioid Exposure: A Retrospective Matched Case-Control Study.

    Pharmacotherapy·2026
    Same journal

    Voriconazole Dosing and Therapeutic Drug Monitoring in Patients Before and After Liver Transplantation.

    Pharmacotherapy·2026
    Same journal

    Quantifying the Serum Magnesium Response and Predictors of Response Following Intravenous Magnesium Replacement in Critically Ill Patients.

    Pharmacotherapy·2026
    See all related articles

    Individualized vancomycin dosing is essential. A simplified regimen based on lean body weight and estimated creatinine clearance achieved therapeutic vancomycin serum levels in most patients, simplifying treatment initiation.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Infectious Diseases

    Background:

    • Standard vancomycin dosing (500 mg q6h or 1.0 g q12h) is inadequate due to patient variability.
    • Individualized vancomycin dosing is crucial for optimizing therapeutic outcomes and minimizing toxicity.

    Purpose of the Study:

    • To develop and evaluate a simplified vancomycin dosing method.
    • To assess the practicality and efficacy of the simplified regimen in achieving target vancomycin serum concentrations.

    Main Methods:

    • Prospective evaluation in 30 patients with varying renal function (creatinine clearance 19-113 ml/min).
    • Dosing based on lean body weight (8.3 ± 0.6 mg/kg) and predicted interval by estimated creatinine clearance.
    • Monitoring of vancomycin peak and trough serum concentrations.

    Related Experiment Videos

    Main Results:

    • The simplified regimen achieved desired vancomycin serum levels in the majority of patients.
    • 25 out of 30 patients required no dosage modifications.
    • Mean peak: 26.9 ± 5.8 µg/ml; Mean trough: 7.7 ± 2.0 µg/ml.

    Conclusions:

    • The simplified vancomycin dosing regimen is practical and effective.
    • This method simplifies vancomycin initiation, requiring minimal patient data.
    • Individualized dosing based on weight and renal function improves therapeutic drug monitoring.