Antimicrobial and Anticancer Activities of Lactiplantibacillus plantarum Probio87 Isolated from Human Breast Milk
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View abstract on PubMed
Summary
This summary is machine-generated.Lactiplantibacillus plantarum Probio87 shows strong probiotic potential for vaginal health, exhibiting robust physiological traits, selective antimicrobial activity, and significant anticancer effects against cervical cancer cells in vitro.
Area Of Science
- Microbiology and Probiotics
- Cancer Biology
- Women's Health
Background
- The study investigates the in vitro probiotic potential of Lactiplantibacillus plantarum Probio87 (Probio87).
- Focus areas include physiological robustness, safety, antimicrobial properties, and anticancer activity.
- Relevance to vaginal and cervical health is a key consideration.
Purpose Of The Study
- To evaluate the probiotic characteristics of Lactiplantibacillus plantarum Probio87.
- To assess its safety, including antibiotic susceptibility.
- To determine its antimicrobial and anticancer effects relevant to vaginal and cervical health.
Main Methods
- Assessed acid/bile tolerance, mucin adhesion, and carbohydrate utilization.
- Evaluated prebiotic preferences (FOS, GOS, inulin) and antibiotic susceptibility.
- Tested cell-free supernatant (CFS) antimicrobial activity and effects on vaginal lactobacilli; assessed anticancer effects on cervical cancer cell lines (HeLa, CaSki, C-33A).
Main Results
- Probio87 demonstrated strong acid/bile tolerance, mucin adhesion, and broad carbohydrate utilization, favoring FOS/GOS.
- It met EFSA antibiotic safety standards; CFS showed potent antimicrobial activity, inhibiting Candida albicans and selectively inhibiting Lactobacillus iners.
- CFS significantly reduced cervical cancer cell proliferation and angiogenesis, induced apoptosis and cell cycle arrest in HPV-positive cells.
Conclusions
- Lactiplantibacillus plantarum Probio87 exhibits significant probiotic potential with safe, selective antimicrobial and anticancer properties.
- Its ability to modulate vaginal microbiota and target cervical cancer pathways is promising.
- Supports application in functional foods or therapeutic strategies for vaginal and cervical health.
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