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Updated: Sep 11, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

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Topical MTH1 Inhibition Suppresses SKP2-WNT5a-Driven Psoriatic Hyperproliferation

Cecilia Bivik Eding1, Ines Köhler1, Lavanya Moparthi1

  • 1Ingrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.

International Journal of Molecular Sciences
|August 14, 2025
PubMed
Summary

Topical TH1579 effectively treats psoriasis by reducing inflammatory cell infiltration and keratinocyte proliferation. This novel therapy targets the SKP2/WNT5a pathway, offering new hope for mild-to-moderate psoriasis patients.

Keywords:
MTH1inflammationkeratinocytesproliferationpsoriasisskin

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