Chronic sclerosing ureteritis and nephrogenic adenoma of the ureter in analgesic abuse

A 44-year old women with 8 years of analgesic abuse developed bilateral ureteral stenosis with urine congestion and manifestations of renal insufficiency. The resected parts of the ureters were affected by chronic productive inflammation with pronounced capillarosclerosis characteristic of analgesic abuse and largely responsible for the stenosis of the lumina. In addition there was a nephrogenic adenoma in the left ureter, so far almost exclusively described in the urinary bladder and prostatic urethra. Its relation to the analgesic abuse is under discussion.