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Updated: Sep 11, 2025

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Nuclear Receptors in Bladder Cancer: Insights into miRNA-Mediated Regulation and Potential Therapeutic Implications

José Javier Flores-Estrada1, Adriana Jiménez1, Georgina Victoria-Acosta1

  • 1División de Investigación, Hospital Juárez De México, Mexico City 07760, Mexico.

International Journal of Molecular Sciences
|August 14, 2025
PubMed

Insights

Nuclear receptors (NRs) and microRNAs (miRNAs) form complex regulatory networks in bladder cancer (BCa). Understanding these interactions offers new targets for precision oncology and improved treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Nuclear receptors (NRs) are crucial transcription factors involved in physiological processes and cancer.
  • Dysregulated NR signaling in bladder cancer (BCa) impacts tumor initiation, progression, resistance, and immune evasion.
  • Emerging evidence reveals significant crosstalk between NRs and microRNAs (miRNAs) in BCa pathogenesis.

Purpose of the Study:

  • To provide an integrated overview of molecular interactions between NRs and miRNAs in BCa.
  • To elucidate how miRNAs regulate NR expression and function, and vice versa.
  • To highlight therapeutic strategies targeting these NR-miRNA networks.

Main Methods:

  • Literature review focusing on molecular interactions between NRs and miRNAs in BCa.
  • Analysis of regulatory feedback loops formed by NR-miRNA interplay.
  • Discussion of specific miRNA-NR interactions impacting key cancer hallmarks.

Main Results:

  • miRNAs regulate NR expression and function, while NRs influence miRNA biogenesis, creating feedback loops.
  • Specific interactions affect epithelial-to-mesenchymal transition, metabolic reprogramming, angiogenesis, and chemoresistance.
  • NR-miRNA networks are implicated in BCa progression and therapeutic resistance.

Conclusions:

  • NR-miRNA interactions are central to BCa development and progression.
  • Targeting these networks offers potential for novel diagnostic biomarkers and personalized treatments.
  • Further understanding can advance precision oncology in urological cancers.
Keywords:
RNA-based therapybladder cancergene regulationmiRNAsnuclear receptorstherapeutic response

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